In this award-winning film, a boy growing up in Astoria, New York in the 1980s watches as his friends and acquaintances die, go to prison or ruin their lives with drug use. He becomes convinced that various so-called "saints" have saved him from this kind of destiny.

The all-star cast includes Robert Downey Jr., Channing Tatum, Rosario Dawson, Shia LaBeouf, Eric Roberts and two-time Academy Award® winner Dianne Wiest.